General Description
Headache is a term referring to pain anywhere in the network of
nerves in the face, mouth, scalp, throat, the muscles of the head,
and the blood vessels along the surface and at the base of the brain.
The bones of the skull and the tissues of the brain itself do not
hurt because they lack pain-sensitive nerve fibers. There are four
general categories of headache: vascular, muscle contraction (or
tension), traction, and inflammatory.1 Vascular
headaches (a group that includes migraine) are so named because
they are thought to involve abnormal function of the brain's vascular
system. Muscle contraction headaches appear to involve the tightening
or tensing of facial and neck muscles. Traction and inflammatory
headaches are symptoms of other disorders, ranging from stroke to
sinus infection. Some people have more than one type of headache.
Muscle-contraction (tension) headache
Ninety percent of all headaches are classified as tension/muscle-contraction
headaches.1 The pain is generally described
as a feeling of pressure being applied to the neck or head. The
primary cause of pain in these headaches is believed to be sustained
muscle tension, although restricted blood flow may also be a contributing
factor. Acute tension headache is a temporary muscle-contraction
headache caused by physical or emotional stress. The pain usually
subsides after the period of stress is over. In contrast, chronic
muscle-contraction headaches may last for weeks, months, and sometimes
years. In many cases, these chronic headaches are caused by depression
and anxiety. Acute tension headaches are generally treated with
muscle relaxants or analgesics like aspirin and acetaminophen.
For more severe cases, stronger analgesics, such as codeine, are
sometimes prescribed. People with chronic muscle-contraction headaches
are often treated with non-drug therapies such as biofeedback
and relaxation training. Antidepressants may also be prescribed
when headache is associated with underlying depression.
Classic migraine
The most common type of vascular headache is migraine. Migraine
headaches are usually characterized by severe pain on one or both
sides of the head, upset stomach, sensitivity to light and noises,
and (at times) blurred vision. The two most prevalent types of
migraine are classic and common migraine. The main difference
between the two types is the appearance of neurological symptoms
10 to 30 minutes before a classic migraine attack. These symptoms,
or aura, may include: visual sensations such as flashing lights
or zig-zagging lines, temporary loss of vision, speech difficulty,
weakness of an arm or leg, tingling of the face or hands, and
confusion. The pain of a classic migraine is described as intense,
throbbing, or pounding felt in the forehead, temple, ear, jaw,
or around the eye. Classic migraine starts on one side of the
head but may eventually spread to the other side. Attacks typically
last 1 to 2 days.1
Common migraine
The common migraine (a term that reflects the disorder's greater
occurence in the general population) is not preceded by an aura,
but some people experience a variety of vague symptoms beforehand,
including mental fuzziness, mood changes, fatigue, and unusual
fluid retention. During the headache phase of a common migraine,
a person may experience diarrhea, increased urination, nausea,
and vomiting. Pain may last 3 to 4 days. Both classic and common
migraine can strike as often as several times a week, or as rarely
as once every few years.1 Although both types
can occur at any time, some people experience migraines at predictable
times, such as near the days of menstruation or on a Saturday
morning after a stressful work week. Although both men and women
may suffer from migraines, the condition is more common in adult
women. Although migraines may develop as early as infancy, the
disorder most often begins between the ages of 5 and 35.1
Contributing factors
Although scientists are still uncertain about exactly what causes
migraine headaches, it is generally believed that they result
from changes in blood flow within the brain. People who get migraine
headaches appear to have blood vessels that overreact to various
triggers, resulting in abnormal constriction and dilation of blood
vessels, impaired blood flow to the brain, and the release of
pain-producing substances known as prostaglandins. This abnormality
in the regulation of blood vessels appears to be inherited; many
sufferers have a family history of migraine. Migraine attacks
can be triggered by a variety of factors, such as hormonal changes
(as may occur with menstruation, menopause, or the use of birth
control pills), stress, food allergies, weather conditions, glaring
or flickering lights, odors, or fatigue. Scientists report that
people can develop migraine not only during periods of stress
but also afterwards when their vascular systems are still reacting.1
Conventional treatment
The most common methods of preventing and controlling migraine
and other vascular headaches include drug therapy, biofeedback
training, stress reduction, and elimination of certain "triggering"
foods. Drug therapy focuses on preventing attacks and relieving
pain when attacks occur. One of the most commonly used drugs for
relief of migraine symptoms is ergotamine tartrate, a vasoconstrictor
that helps control the painful dilation of blood vessels if taken
during the early stages of a migraine attack. If a migraine has
been in progress for over an hour, this drug probably will not
help.1 Drugs used for prevention of migraine
attacks include methysergide maleate, which counteracts blood
vessel constriction; propranolol hydrochloride, which stops blood
vessel dilation; and amitriptyline, an antidepressant. A class
of drugs known as MAO inhibitors may also help prevent migraine.
These drugs block an enzyme called monoamine oxidase, which normally
helps nerves cells absorb serotonin, a brain chemical that causes
arteries to constrict. In recent years, drugs that mimic the action
of serotonin have been developed for prevention of migraine, but
many of these drugs can have adverse side effects. The natural
serotonin precursor 5-HTP, which is sold as a dietary supplement,
has been shown in several studies to reduce the frequency and
severity of migraine attacks2-6 and appears
to have fewer, less serious side effects than many migraine drugs.5,6
Nutritional/lifestyle considerations
Several dietary and lifestyle factors can contribute to migraines.
Stress is believed to be a major contributor, and relaxation techniques
such as yoga and biofeedback help many people reduce the number
of migraine attacks. Regular exercise, such as swimming or vigorous
walking, can also reduce the frequency and severity of migraine
headaches.1 Some people benefit from dietary
measures such as the elimination of migraine-triggering foods
and food additives. In some people, migraine results from hypoglycemia
(low blood sugar), which may be controlled in many cases by consuming
smaller, more frequent meals.1 Certain nutrients
may also play a protective role against migraines. In some studies,
high doses (400 mg/day) of riboflavin produced significant reduction
in migraine attacks in the majority of test subjects.7-9
Other studies suggest vitamin D,10,11 calcium,10,11
and magnesium 12-17 may also be useful in
migraine prevention. Herbalists commonly recommend feverfew for
migraine prevention, and recent studies indicate there may be
some value in this traditional remedy.18-22
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